Nicotinamide Mononucleotide (NMN)
Updated: 2025-10-08
⚡ Overview
Nicotinamide Mononucleotide (NMN) is a direct precursor of NAD⁺, an essential coenzyme for mitochondrial energy production, DNA repair, and neural function.
It is studied for its potential to support cellular longevity and metabolic vitality, especially as NAD⁺ levels naturally decline with age.
🟢 Proven Benefits
- Cellular energy & NAD⁺: increases intracellular NAD⁺, enhancing mitochondrial respiration and efficiency.
- Longevity & repair: activates SIRT1/SIRT3 pathways involved in DNA protection and cellular regeneration.
- Cognition & neuroprotection: supports microcirculation and neuronal health, with early positive human data.
- Metabolic balance: improves insulin sensitivity and glucose tolerance in animal and early clinical studies.
🟡 Still Under Study
- Long-term effects on human lifespan remain unproven.
- Current clinical trials are small-scale and short-term (≤ 12 weeks).
- The comparison between NMN and NR (Nicotinamide Riboside) remains biologically context-dependent.
- Oral bioavailability varies by form (standard vs. liposomal or sublingual).
🔴 What It Does Not Do
- Does not slow aging directly in humans.
- Does not replace healthy habits such as diet, sleep, and exercise.
- Not a short-term stimulant — its effects are gradual and cellular.
💊 Dosage & Usage
General guidance — not a medical prescription
- 250–500 mg/day, taken in the morning (with or without food).
- Forms: pure NMN, sublingual, liposomal, or powder.
- Can be combined with NR, CoQ10, ALA, or Resveratrol for synergistic longevity effects.
- Storage: keep in a cool, dark place to preserve stability.
⚠️ Safety
- Well tolerated up to 900 mg/day in human trials.
- Occasional reports of mild nausea or hot flashes.
- Long-term safety data (>2 years) remain limited.
- Not recommended during pregnancy or breastfeeding due to lack of data.
⚠️ Risks & Interactions
- Consult a professional if taking diabetes, liver, or cholesterol medications.
- May interact with other NAD⁺ boosters or metabolic regulators.
✅ Quality Tips
- Verify purity (≥99%) and obtain a Certificate of Analysis (COA).
- Prefer liposomal or sublingual formulations for better absorption.
- Avoid unverified products — some may contain NR or nicotinamide adulteration.
- Store refrigerated after opening to maintain potency.
📚 References
⚠️ Educational information. Always seek professional advice.