Alpha-Lipoic Acid (ALA)
Updated: 2025-10-08
⚡ Overview
Alpha-Lipoic Acid (ALA) is a universal antioxidant, active in both water- and fat-soluble environments.
As a Krebs cycle cofactor, it supports mitochondrial energy production and regenerates key antioxidants such as vitamin C, vitamin E, and glutathione.
Commonly paired with ALCAR and CoQ10, ALA is studied for its role in neuroprotection, energy metabolism, and insulin sensitivity.
🟢 Proven Benefits
- Energy & mitochondria: enhances energy metabolism and ATP production.
- Central antioxidant: recycles vitamin C, E, and glutathione → reduces cellular oxidative stress.
- Metabolism & glucose: improves insulin sensitivity and supports blood sugar regulation.
- Brain & nerves: shows neuroprotective effects in peripheral neuropathies and may aid memory.
- Synergy: works well with ALCAR and CoQ10 for mental energy and recovery.
🟡 Still Under Study
- Human evidence for lifespan extension remains inconclusive.
- Cognitive outcomes vary with age, dosage, and form (R-ALA vs racemic mix).
- Limited long-term data (>1 year of use).
🔴 What It Does Not Do
- Does not replace medical treatment for diabetes.
- Not an immediate stimulant.
- No proven “liver detox” effects.
💊 Dosage & Use
General guidance — not a prescription
- 300–600 mg/day, taken once or twice daily.
- R-ALA (natural form) offers superior bioavailability.
- Best taken on an empty stomach, 30–60 minutes before meals.
- Recommended combination: R-ALA + ALCAR + CoQ10 for mitochondrial and cognitive support.
⚠️ Safety
- Well tolerated at standard doses.
- Rare effects: mild nausea, acid reflux, or temporary hypoglycemia.
- Avoid unsupervised use if pregnant or under diabetic medication.
⚠️ Risks & Interactions
- Consult a professional if using hypoglycemic agents or diabetes medication.
- May enhance the effects of antioxidants or insulin-sensitizing compounds.
✅ Quality Tips
- Choose R-ALA (natural form) over synthetic RS blends.
- Look for purity-tested and thermally stable formulations.
- Store in a cool, dry place, away from light and humidity.
📚 References
⚠️ Educational information. Always seek professional advice.